Pathophysiological and morphological aspects of congenital hyperinsulinism. Review
نویسندگان
چکیده
منابع مشابه
[Congenital hyperinsulinism].
In the last five years, our knowledge about the heterogenous syndrome of congenital hyperinsulinism (HI) has expanded explosively. HI may be familiar or sporadic, mild or severe, transitory or persistent, and histologically focal or diffuse. At least 63 disease-causing mutations have been found in the genes for the beta cell's ATP-dependent potassium channel, whose elements are the sulphonylure...
متن کاملMolecular mechanisms of congenital hyperinsulinism.
Congenital hyperinsulinism (CHI) is a complex heterogeneous condition in which insulin secretion from pancreatic β-cells is unregulated and inappropriate for the level of blood glucose. The inappropriate insulin secretion drives glucose into the insulin-sensitive tissues, such as the muscle, liver and adipose tissue, leading to severe hyperinsulinaemic hypoglycaemia (HH). At a molecular level, ...
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ژورنال
عنوان ژورنال: Translational Medicine
سال: 2020
ISSN: 2410-5155,2311-4495
DOI: 10.18705/2311-4495-2020-7-2-12-20